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Beginner's Guide to E&L

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Jason Creasey
April 13, 2021

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Multidetector systems for E&L

Mark Jordi has published a series of articles on use of multiple detectors (LC-UV,LC-CAD, GC-FID, GC-MS, LC-MS) as a mechanism to ensure correct relative response factors are used in extractable screening studies as an alternative to very high uncertainty values in setting AETs.


Reducing relative response factor variation using a multidetector approach for extractables and leachables (E&L) analysis to mitigate the need for uncertainty factors - PubMed
pubmed.ncbi.nlm.nih.gov
Reducing relative response factor variation using a multidetector approach for extractables and leachables (E&L) analysis to mitigate the need for uncertainty factors - PubMed
Characterization of Extractables and Leachables (E&Ls) is an important aspect of product quality in important fields such as pharmaceuticals, medical devices and food contact materials. The main goal of an E&L study is identification and quantification of those species which may leach from p …



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